Table 1.
Baseline participant demographics and clinical characteristics. Data are shown as mean ± standard deviation (range).
| Total | Female | Male | ||
|---|---|---|---|---|
| Participants (n) | 24 | 16 | 8 | |
| Age, years | 63.04±8.67 (49–81) | 63.88±9.86 (49–81) | 61.38±5.81 (51–68) | |
| Baseline weight, kg | 78.36±20.00 (54.50–131.00) | 68.79±9.94 (54.50–85.40) | 97.49±21.81 (76.30–131.00) | |
| 16 weeks weight, kg | 76.70±20.61 (54.10–131.00) | 67.01±9.27 (54.10–80.80) | 96.10±23.81 (74.10–131.00) | |
| Baseline BMI | 27.80±4.83 (18.50–38.90) | 26.40±4.23 (18.50–33.10) | 30.62±4.98 (24.70–38.90) | |
| 16 weeks BMI | 27.40±5.07 (18.50–38.90) | 25.83±3.92 (18.50–31.90) | 30.56±5.85 (23.60–38.90) | |
| Race | Black | 0 | 0 | 0 |
| White | 23 | 8 | 15 | |
| Other | 1 | 1 | 0 | |
| LDH units | 543 (199–1178) | 483 (199–1178) | 695 (415–684) | |
| B2-microgobulin ug/ml | 2.4 (1.4–6.4) | 2.6 (1.4–6.4) | 2.1 (1.8–2.9) | |
| WBC × 109/L | 37.0 (5.4–167.4) | 34.3 (5.4–121.2) | 42.6 (8.1–167.4) | |
| Hemoglobin g/dL | 13.4 (9.7–15.4) | 12.8 (9.7–14.1) | 14.5 (13.2–15.4) | |
| Platelets × 109/L | 196 (59–280) | 206 (59–280) | 176 (65–274) | |
| Albumin g/dL | 4.5 (4.0–5.1) | 4.5 (4.0–5.0) | 4.5 (4.0–4.9) | |
| Rai stage (n) | 0 | 7 | 5 | 2 |
| I | 4 | 3 | 1 | |
| II | 0 | 0 | 0 | |
| II | 4 | 3 | 1 | |
| IV | 9 | 5 | 4 | |
| Prior lines of therapy | ||||
| 0 | 15 | 10 | 5 | |
| 1 | 7 | 5 | 2 | |
| 2 | 2 | 1 | 1 | |
| Treatment (n) | None | 12 | 7 | 5 |
| Acalabrutinib | 2 | 2 | 0 | |
| Ibrutinib | 6 | 3 | 3 | |
| Obinutuzumab | 1 | 1 | 0 | |
| Venetoclax | 4 | 3 | 1 | |
| Zanubrutinib | 2 | 2 | 0 | |
| Combination | 3 | 2 | 1 | |
| Duration of current treatment, months | 16.4 (5–36) | 12.6 (5–24) | 21.4 (5–36) | |
| CLL comorbidity index score | 0 | 9 | 6 | 3 |
| 1 | 8 | 7 | 1 | |
| 2–3 | 7 | 3 | 4 | |
| del 11q† | 1 | 0 | 1 | |
| del 13q† | 12 | 8 | 4 | |
| del 17p† | 1 | 1 | 0 | |
| Tri 12† | 4 | 2 | 2 | |
| mutated TP 53 | 1 | 0 | 1 |
†
indicates fluorescence in situ hybridization (FISH) BMI: body mass index, CLL: chronic lymphatic leukemia LDH: lactate dehydrogenase, WBC: white blood cell count