Table 3.

Comparisons of the allelic and genotype distributions of the eight studied SNPs between the schizophrenia subgroups and the healthy control group.

SNP	Major/minor allele (MAF)#	Group	Genotype n (%)				Allele n (%)				OR	95% CI
			MM	Mm	mm	p value	M	m		p value
TH
rs10770141	G > A [A:0.068]	HC	359 [85.7]	57 [13.6]	3 [0.7]	0.696	775 [92.5]	63 [7.5]		0.837
		Non-TRS	457 [86.2]	72 [13.6]	1 [0.2]		986 [93.0]	74 [7.0]			0.923	0.651–1.309
		TRS	371 [87.1]	52 [12.2]	3 [0.7]		794 [93.2]	58 [6.8]			0.910	0.621–1.301
rs6356	A > G [G:0.325]	HC	201 [49.4]	170 [41.8]	36 [8.8]	0.317	572 [70.3]	242 [29.7]		0.396
		Non-TRS	238 [45.8]	235 [45.2]	47 [9.0]		711 [68.4]	329 [31.6]			1.094	0.896–1.335
		TRS	215 [52.1]	158 [38.3]	40 [9.7]		588 [71.2]	238 [28.8]			0.957	0.773–1.184
DRD2
rs1800497	G > A [A:0.373]	HC	205 [45.7]	184 [41.0]	60 [13.4]	0.311	594 [66.1]	304 [33.9]		0.256
		Non-TRS	214 [40.2]	239 [44.8]	80 [15.0]		667 [62.6]	399 [37.4]			1.169	0.971–1.407
		TRS	176 [41.1]	196 [46.5]	53 [12.4]		551 [64.4]	305 [35.6]			1.082	0.889–1.317
rs6275	A > G [G:0.432]	HC	176 [37.1]	215 [45.3]	84 [17.7]	0.287	567 [59.7]	383 [40.3]		0.183
		Non-TRS	167 [31.5]	261 [49.2]	103 [19.4]		595 [56.0]	467 [44.0]			1.162	0.973–1.388
		TRS	148 [34.7]	211 [49.4]	68 [15.9]		507 [59.4]	347 [40.6]			1.013	0.893–1.223
COMT
rs4680	G > A [A:0.317]	HC	205 [42.8]	210 [43.8]	64 [13.4]	0.288	620 [64.7]	338 [35.3]		0.310
		Non-TRS	243 [44.9]	231 [43.2]	61 [11.4]		717 [67.0]	353 [33.0]			0.903	0.751–1.085
		TRS	192 [44.9]	198 [46.3]	38 [8.9]		582 [68.0]	274 [32.0]			0.864	0.710–1.050
SLC6A3
rs3756450	A > G [G:0.469]	HC	133 [30.8]	210 [48.6]	89 [20.6]	0.006	476 [55.1]	388 [44.9]		<0.001
		Non-TRS	112 [22.6]	250 [50.4]	134 [27.0]		474 [47.8]	518 [52.2]			1.341	1.117–1.620
		TRS	124 [30.8]	200 [49.8]	78 [19.4]		448 [55.7]	356 [44.3]			0.975	0.804–1.183
rs420422	G > A [A:0.392]	HC	152 [35.8]	202 [47.6]	70 [16.5]	0.330	506 [59.7]	342 [40.3]		0.119
		Non-TRS	214 [41.6]	233 [45.3]	67 [13.0]		661 [64.3]	367 [35.7]			0.822	0.681–0.991
		TRS	157 [37.8]	200 [48.2]	58 [14.0]		514 [61.9]	316 [38.1]			0.910	0.748–1.107
			10 10	10 X	X Y		10 repeat	9 repeat	Others
40-bp VNTR	10 > others [10: 0.93]#	HC	93 [91.2]	9 [8.8]	0 [0]	0.004	195 [95.6]	5 [2.5]	4 [2.0]	0.023
		Non-TRS	79 [80.6]	19 [19.4]	0 [0]		177 [89.8]	8 [4.1]	12 [6.1]		2.448	1.086–5.518
		TRS	77 [77.8]	17 [17.2]	5 [5.1]		171 [86.8]	15 [7.6]	11 [5.6]		3.294	1.502–7.225

SNP, Single nucleotide polymorphism; VNTR, Variable number of tandem repeats.^#From Sano et al. (60).