Table 1. Summary results of MR (target gut microbiome on esophageal cancer).

Taxa	Exposure	Outcome	Nsnp	Methods	Beta	SE	OR (95%CI)	P-value	Heterogeneity		Horizontal pleiotrop
									Cochran’s Q	P-value	Egger intercept P	MR-PRESSO P
Family	Porphyromonadaceae	Esophageal cancer	9	Inverse variance weighted	-0.432	0.219	0.65 (0.42-0.99)	0.048	6.708	0.568	0.279	0.6
Genus	Candidatus Soleaferrea	Esophageal cancer	11	Inverse variance weighted	-0.248	0.125	0.78 (0.61-0.99)	0.048	10.878	0.367	0.594	0.38
Genus	Catenibacterium	Esophageal cancer	5	Inverse variance weighted	0.196	0.134	1.31 (1.01- 1.71)	0.044	1.795	0.773	0.924	0.78
Genus	Eubacterium coprostanoligenes	Esophageal cancer	13	Inverse variance weighted	0.355	0.171	1.43 (1.02-2.00)	0.038	9.402	0.668	0.718	0.68
Genus	Marvinbryantia	Esophageal cancer	10	Inverse variance weighted	0.340	0.173	1.41 (1.01-1.97)	0.049	3.315	0.950	0.813	0.97
Genus	Ruminococcaceae UCG010	Esophageal cancer	6	Inverse variance weighted	0.466	0.220	1.59 (1.03- 2.46)	0.034	2.971	0.704	0.863	0.69
Genus	Ruminococcus1	Esophageal cancer	10	Inverse variance weighted	0.381	0.192	1.46 (1.01-2.13)	0.047	7.057	0.631	0.090	0.62
Genus	Sutterella	Esophageal cancer	12	Inverse variance weighted	0.414	0.166	1.51 (1.09-2.10)	0.012	6.918	0.805	0.116	0.93