Table 3.
Concentrations of angiogenic markers in PE and non-PE women according to physical activity category, mean estimate/model-based mean (95% CI).
| PE |
Non-PE |
p Value |
||||||
|---|---|---|---|---|---|---|---|---|
| Physically activea | Physically inactiveb | Physically activea | Physically inactiveb | Active vs inactive | Active vs inactivec | Group * exercise interaction | Group * exercise interactionc | |
| s-Flt1 (pg/ml) | ||||||||
| I trimester | 1311.6 (1208.3 − 1422.3) (n = 104) | 1280.49 (1146 − 1430.8) (n = 56) | 1418 (1301.1 − 1546.9) (n = 94) | 1399.7 (1264 − 1550) (n = 66) | 0.707 | 0.517 | 0.919 | 0.980 |
| III trimester | 10938 (9623.9 − 12431.6) (n = 87) | 9348.8 (7918.8 − 11025.9) (n = 52) | 4505.3 (3565.3 − 5693) (n = 26) | 4514.3 (3480.7 − 5860.6) (n = 21) | 0.454 | 0.343 | 0.441 | 0.143 |
| s-PlGF (pg/ml) | ||||||||
| I trimester | 31.7 (29.3 − 34.3) (n = 104) | 28.5 (25.6 − 31.8) (n = 55) | 41.6 (38.3 − 45.3) (n = 94) | 41.0 (37.1 − 45.2) (n = 66) | 0.202 | 0.284 | 0.347 | 0.420 |
| III trimester | 78.7 (68.2 − 90.9) (n = 87) | 88.9 (73.7 − 107) (n = 52) | 150.4 (115.5 − 195.6) (n = 26) | 170.5 (127.1 − 228.6) (n = 21) | 0.291 | 0.285 | 0.981 | 0.918 |
| s-Eng (ng/ml) | ||||||||
| I trimester | 6.1 (5.8 − 6.46) (n = 103) | 5.7 (5.3 − 6.1) (n = 56) | 5.7 (5.4 − 6.0) (n = 94) | 5.4 (5.1 − 5.8) (n = 66) | 0.055 | 0.419 | 0.726 | 0.802 |
| III trimester | 43.6 (38.2 − 50.0) (n = 87) | 37.8 (31.8 − 44.9) (n = 52) | 19.5 (15.3 − 24.9) (n = 26) | 14.9 (11.3 − 19.5) (n = 21) | 0.055 | 0.631 | 0.553 | 0.939 |
| sFlt1/s-PlGF | ||||||||
| I trimester | 41.3 (37.6 − 45.4) (n = 104) | 45.4 (39.9 − 51.6) (n = 55) | 34.1 (30.8 − 37.6) (n = 94) | 34.2 (30.4 − 38.4) (n = 66) | 0.396 | 0.122 | 0.423 | 0.410 |
| III trimester | 138.9 (114.0 − 169.2) (n = 87) | 105.2 (81.5 − 135.8) (n = 52) | 30.0 (20.9 − 43.0) (n = 26) | 26.5 (17.7 − 39.6) (n = 21) | 0.210 | 0.834 | 0.630 | 0.324 |
Data are presented as median (range).
aExercise 2 − 3 times/week or more. bExercise less than 2 − 3 times/week. cAdjusted for pre-pregnancy BMI, parity, mother’s age at birth and smoking status during pregnancy.