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. 2024 Mar 11;46(1):2327495. doi: 10.1080/0886022X.2024.2327495

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — Quercetin activates Nrf2 to inhibit ferroptosis in DKD rats. (A) Western blot analyses of GPX4, xCT, ACSL4, and Nrf2 protein levels in kidney tissues. (B,D) Semi-quantitative assessments of GPX4, xCT, and ACSL4 from immunoblots. (E) Semi-quantitative analysis of Nrf2 from immunoblots. (F) Immunohistochemical staining for Nrf2 in kidney tissues (scale bar = 50 μm). (G) Quantification of Nrf2 expression from Figure 3(F). Groups: CON (control), DKD (DKD model), DKD + QCT (DKD rats treated with Quercetin), DKD + Fer-1 (DKD rats treated with Ferrostatin-1). Data are mean ± SD. Significance levels: ****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05, determined by one-way ANOVA.