Figure 5. Schematic illustration.
CYPs/EETs are highly expressed in PDAC and EETs inhibit the erastin-induced ferroptosis in a PPARγ-dependent manner in PANC-1 cells. ARA: Arachidonic acid; CYP2J2: Cytochrome P4502J2; EETs: Epoxyeicosatrienoic acids; PPARγ: Peroxisome proliferation-activated receptor γ; GPX4: Glutathione peroxidase; PDAC: Pancreatic ductal adenocarcinoma.