TABLE 2.

Observed Versus Simulated Dose and Concentration at 24 weeks

Outcome Variable	Observed	Simulated	P
Dose* (mg)	0.65 (0.50–1.00)	0.43 (0.20–0.60)	0.014†
Concentration* (µg/L)	7.55 (4.50–11.60)	5.39 (4.56–7.02)	0.023†
N in therapeutic range (3.5–7 µg/L)‡	4 (16.7%)	15 (62.5%)	0.003§
N below therapeutic range (<3.5 µg/L)‡	5 (20.8%)	2 (8.3%)	0.413
N above therapeutic range (>7 µg/L)‡	15 (62.5%)	7 (29.2%)	0.043†

^*Presented as median (IQR) for continuous variables.

^†P < .05.

^‡Presented as number of cases (%) for categorical variables.

^§P < .01.