TABLE 4.
Review of Methodology and Analytical Quality of Laboratory Studies Measuring CLO and NCLO
| Author | Method | Description | Detection/Quantification | CV Intraday | CV Interday | |||
| CLO | NCLO | CLO | NCLO | CLO | NCLO | |||
| Alfaro et al61 | HPLC plasma | Yes | No/20 | No/20 | <15% | <15% | <15% | <15% |
| Bez et al59 | ND serum | No | No | No | No | No | No | No |
| Jiménez-Fernández et al63 | ND plasma | No | No | Not studied | No | Not studied | No | Not studied |
| Kumra et al7 | HPLC serum | No* | No | Not studied | No | Not studied | No | Not studied |
| Piscitelli et al62 | HPLC plasma | No | No | No | <10% | <10% | <10% | <10% |
| Schulz et al58 | HPLC serum | Schulz et al64 | No | No | <10% | <10% | <6% | <6% |
| Wohkittel et al60 | HPLC serum | Yes | 10/No | Not studied | <2% | Not studied | <2% | Not studied |
*
They refer to a particular laboratory but do not provide a description of the method.
CLO, clozapine; CV, coefficient of variation; NCLO, norclozapine; ND, not described.