Table 2.
Distribution of anamnestic and phenotypic data of 542 atypical melanocytic palmoplantar lesion (aMPPL) cases, grouped according to seven macro-areas (four on the sole and three on the palm).
| n (%)/Mean ± SD | |||
|---|---|---|---|
| Lesion Data | MMs (113) | Nevi (429) | p |
| Maximum diameter | 17.39 ± 12.47 | 6.58 ± 3.58 | <0.001 |
| Body site | 0.285 | ||
| Four macro-areas of the sole * | 98 (87.5%) | 392 (91.4%) | |
|
21 (21.4%) | 90 (23.0%) | |
|
21 (21.4%) | 66 (16.8%) | |
|
29 (29.6%) | 200 (51.0%) | |
|
27 (27.6%) | 36 (9.2%) | |
| Three macro-areas of the palm # | 14 (12.5%) | 37 (8.6%) | |
|
3 (21.4%) | 9 (24.3%) | |
|
7 (50.0%) | 10 (27.0%) | |
|
4 (28.6%) | 18 (41.6%) | |
| Patient Data | |||
| Age | 65.30 ± 14.79 | 41.33 ± 16.81 | <0.001 |
| Male | 55 (48.6%) | 140 (32.6%) | |
| Female | 58 (51.3%) | 289 (67.4%) | 0.002 |
| Anamnestic Data/Risk Factors | |||
| Personal/family history of melanoma—1st-degree relative | 0.520 | ||
| No | 9 (7.9%) | 70 (16.3%) | |
| Yes | 0 (0.0%) | 11 (2.5%) | |
| History of sunburns (>3) in childhood below the age of 14 years | |||
| No | 25 (22.1%) | 50 (11.6%) | |
| Yes | 7 (0.6%) | 34 (7.9%) | |
| Chronic traumatism on soles | |||
| No | 15 (13.2%) | 129 (30.0%) | |
| Yes | 0 (0%) | 10 (23.3%) | |
| Chronic traumatism on palms | |||
| No | 10 (8.8%) | 94 (21.9%) | |
| Yes | 0 (%) | 1 (0.2%) | |
| PHENOTYPIC TRAITS | |||
| Presence of >100 common nevi or >10 dysplastic nevi | 1.000 | ||
| No | 7 (6.1%) | 60 (13.9%) | |
| Yes | 3 (2.6%) | 21 (4,8%) | |
| Phototype (%) | 100% | 100% | 0.717 |
| II | 19 (29.7%) | 75 (25.8%) | |
| III | 44 (68.8%) | 204 (70.1%) | |
| IV | 1 (1.6%) | 10 (3.4%) | |
| V | 0 (0.0%) | 2 (0.7%) | |
| Pheomelanin phenotype | |||
| No | 17 (15.0%) | 48 (11.1%) | 0.610 |
| Yes | 9 (7.9%) | 26 (6.0%) | |
| Presence of green/light blue/blue eyes | |||
| No | 23 (20.3%) | 53 (12.3%) | 0.320 |
| Yes | 18 (15.9%) | 33 (7.6%) | |
| Presence of blond hair | |||
| No | 14 (12.3%) | 55 (12.8%) | 0.430 |
| Yes | 26 (23%) | 67 (15.6%) | |
* SOLE SUBAREAS: Toe area (plantar surface of the fingers + lateral surface of the fingers + interdigital spaces); eminence of the sole area (anterior eminence + central eminence + antero-medial eminence); plantar arch area; and heel. # PALM SUBAREAS: Finger area (fingertips + lateral surface of the fingers + interdigital spaces + volar surface of the finger + proximal phalangeal surface); palmar lateral area (metacarpal area + hypotenar); and palmar medial (thenar + central metacarpal).