Figure 5.
Key profibrotic signaling cascades are regulated by YB-1. Differential gene expression analysis of WNT signaling components, YAP/TAZ target genes, and TGFβ signaling components in the kidneys of wild-type and Ybx1ΔRosaERT+TX animals that underwent ureteral obstruction (tissue analyzed on UUO day 6). The top 10 down- and up-regulated genes are listed and the expression levels of the profibrotic signaling components are visualized using green for down-regulated genes in Ybx1ΔRosaERT+TX compared to wild-type kidney tissue, red for up-regulated genes, and orange for a lack of significant regulation between wild-type and Ybx1ΔRosaERT+TX Animals. * The TGFβ ligands have not been analyzed. The expression values of the transcription factors Lef1/Tcf1, YAP/TAZ, and Smad have not been evaluated.