c-MET |
Mesenchymal–epithelial transition factor |
HGF |
Hepatocyte growth factor |
kDa |
Kilodalton |
MET |
MAPK/ERK |
PTK |
Protein tyrosine kinase |
GEFs |
Guanine exchange factors |
GTP |
Guanosine triphosphate |
PIP2 |
Phosphatidylinositol-4,5-diphosphate |
PIP3 |
Phosphatidylinositol-3,4,5-triphosphate |
Akt |
protein kinase B |
SHP2 |
SH2 domain-containing tyrosine phosphatase |
SHC |
SH2 domain-containing transforming protein |
GRB2 |
Growth factor receptor-bound protein 2 |
SOS |
Son of sevenless |
MEK |
Mitogen-activated protein kinase kinase |
ERK |
Extracellular signal-regulated kinases |
PI3K |
Phosphoinositide 3-kinase |
Akt |
Protein kinase B |
BAD |
BCL-2 antagonist of cell death |
MDM2 |
Murine double minute 2 |
STAT3 |
Signal transducer and activator of transcription 3 |
HIF-1 |
Hypoxia-inducible factor-1 |
HIF-1α |
Hypoxia-inducible factor 1-alpha |
mTOR |
Mammalian target of rapamycin |