Table 3.
Treatment parameters of BNCT for HNC patients.
| Parameter | All (N = 160) |
SCCHN (n = 143) |
NSCCHN (n = 17) |
|---|---|---|---|
| 10B conc. after 2-h infusion, ppm (range) | 31.3 (20.9–46.5) | 31.1 (21.0–46.5) | 32.3 (20.9–40.7) |
| Completion of planned irradiation, n (%) | |||
| Completed | 155 (96.9) | 138 (96.5) | 17 (100) |
| Interrupted | 5 (3.1) | 5 (3.5) | 0 |
|
Actual charge amount of accelerator,
C (interquartile range) |
2.44 (2.05–2.95) | 2.45 (2.08–3.03) | 2.29 (2.03–2.59) |
| Prescribed dose of mucosa, n (%) | |||
| <12 Gy-Eq | 14 (8.8) | 11 (7.7) | 3 (17.7) |
| 12 Gy-Eq | 60 (37.5) | 53 (37.1) | 7 (41.2) |
| >12 Gy-Eq | 86 (53.8) | 79 (55.2) | 7 (41.2) |
| Tumor dose, Gy-Eq (interquartile range) | |||
| Dmax | 46.9 (38.9–56.1) | 46.4 (38.7–55.8) | 50.3 (42.7–71.7) |
| Dmin | 26.9 (22.4–32.2) | 26.9 (22.2–31.7) | 25.5 (24.1–37.8) |
| Dmean | 38.7 (32.3–45.3) | 38.4 (32.4–44) | 44.6 (31.2–57.4) |
Abbreviations: BNCT, boron neutron capture therapy; HNC, head and neck cancer; SCCHN, squamous cell carcinoma of the head and neck; NSCCHN, non-squamous cell carcinoma of the head and neck; conc., concentration; Dmax, maximum dose; Dmin, minimum dose; Dmean, mean dose.