Table 1.

Experimental models, melatonin concentrations and markers used in EMT studies.

Tumor	Cell Lines	In Vivo	[Mel]	Upregulated Genes	Downregulated Genes	References
Gastric cancer	AG5, MKN45		0.1 μM–2 mM	E-cadherin	MMP2, MMP9, NF-κB, Snail	[115]
Gastric cancer	MGC80-3, SGC790		0.1–1.5 mM	E-cadherin	Snail, Slug, Wnt/β-catenin, NF-κB	[116]
Gastric cancer	MGC80-3	In vivo lung metastasis	100 mg/Kg/day	E-cadherin	MMP2, MMP9, NF-κB, Snail, Slug, Fibronectin	[122]
Ovarian cancer	SK-OV-3		3.4 mM		ZEB1, ZEB2, Snail, Vimentin	[118]
Ovarian cancer	SK-OV-3	Tumor-bearing mouse model	200 μg/100 g/day		Akt, β-catenin, Slug	[119]
Bladder cancer	UC3		1 μM	E-cadherin	N-cadherin, Fibronectin, Snail, Slug	[117]
Oral cancer	SCC25, SCC9, Tca8113, Cal27, FaDu		1 mM		Akt, Snail, Vimentin	[120]
Breast cancer	MCF-7, MDA-MB-231		1 nM	E-cadherin	Snail	[121]
Breast cancer	MCF-7		1 nM		Twist1, Slug, Akt	[129]
Osteosarcoma	MG-63		200 nM	E-cadherin	N-cadherin, Snail, MMP-9	[123]
Colorrectal cancer	HCT-15 SW620		1–2 mM	E-cadherin	Snail	[124]
Gallbladder cancer	GBC-SD		0.1–2 mM	E-cadherin	N-cadherin, Snail, Vimentin	[125]
Non-small cell lung cancer	H1299		0.1 mM		Snail, Twist1	[126]
Lung cancer	A549, CL1-5		1 mM		Twist1	[127]
Lung cancer	CL1-5		1 mM		Slug, Twist1, β-catenin	[128]