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. 2024 Feb 21;13(5):370. doi: 10.3390/cells13050370

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Chaperone-mediated regulation of intercellular junction integrity under homeostatic conditions and during the stimuli-induced disruption of tissue barriers. (A) The diagram shows the documented interactions of different chaperones and co-chaperones with AJ and TJ proteins in normal epithelia and/or endothelia. Arrows from the membrane-bound GRP94 show the stabilization of TJs and AJs by a yet-to-be-defined mechanism. (B) The diagram depicts the effects of different chaperones on AJ/TJ disassembly in activated/stressed epithelial and endothelial cells. Both chaperone-dependent inhibition and acceleration of junctional disassembly are shown.