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. 2024 Feb 21;13(5):370. doi: 10.3390/cells13050370

Table 3.

Clinical and experimental evidence of UNC-45A-dependent regulation of epithelial barriers.

Loss of UNC-45A Function Human Disease or Experimental Condition Symptoms or Biological Effects References
UNC-45A mutants decreasing its expression Osteo-oto-hepatic-enteric syndrome Diarrhea, cholestasis, and impaired hearing [133,134,135]
UNC-45A mutants decreasing its expression Aagenaes syndrome Cholestasis and lymphedema [136]
UNC-45A mutants decreasing its expression Congenital diarrhea disorder Diarrhea, duodenal villous atrophy, erosion of apical microvilli [137]
Chemically induced UNC-45A mutation Zebrafish Apical vacuolar inclusions, microvilli shortening [137]
UNC-45 mutants decreasing its expression Drosophila Increased intestinal permeability [138]
CRISPR/Cas9-mediated knockout of UNC-45A SK-CO15 and HT-29 human colonic epithelial cells Increased barrier permeability, AJ and TJ disassembly, disorganization of the perijunctional actomyosin belt [138]