UNC-45A mutants decreasing its expression |
Osteo-oto-hepatic-enteric syndrome |
Diarrhea, cholestasis, and impaired hearing |
[133,134,135] |
UNC-45A mutants decreasing its expression |
Aagenaes syndrome |
Cholestasis and lymphedema |
[136] |
UNC-45A mutants decreasing its expression |
Congenital diarrhea disorder |
Diarrhea, duodenal villous atrophy, erosion of apical microvilli |
[137] |
Chemically induced UNC-45A mutation |
Zebrafish |
Apical vacuolar inclusions, microvilli shortening |
[137] |
UNC-45 mutants decreasing its expression |
Drosophila
|
Increased intestinal permeability |
[138] |
CRISPR/Cas9-mediated knockout of UNC-45A |
SK-CO15 and HT-29 human colonic epithelial cells |
Increased barrier permeability, AJ and TJ disassembly, disorganization of the perijunctional actomyosin belt |
[138] |