Table 3.

Factors associated with RFS and OS.

	RFS				OS
	Univariate Analysis		Multivariate Analysis		Univariate Analysis		Multivariate Analysis
	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value
Age
≥70 vs. <70	3.6 (2.0–6.4)	<0.001	3.4 (1.9–6.1)	<0.001	3.0 (1.5–5.9)	<0.001	2.9 (1.5–5.8)	0.002
Sex
M vs. F	1.2 (0.7–2.2)	0.485			1.2 (0.6–2.4)	0.517
Tumor location
M vs. U	1.0 (0.5–2.1)	0.991			1.4 (0.6–3.1)	0.416
L vs. U	0.8 (0.4–1.7)	0.559			0.9 (0.4–2.1)	0.821
Differentiation
Undifferntiated vs. Differentiated	0.6 (0.3–1.1)	0.126			0.6 (0.3–1.2)	0.163
Depth
SM1 vs. M	1.0 (0.5–2.0)	0.931			0.9 (0.4–1.9)	0.720
Tumor size
>20 mm vs. ≤20 mm	1.5 (0.8–2.9)	0.221			1.8 (0.9–3.7)	0.106
Ulcer finding
Presence vs. Absence	1.3 (0.6–3.0)	0.535			1.6 (0.7–3.7)	0.313
Lymph node metastasis
Presence vs. Absence	6.2 (3.2–12.2)	<0.001	——	——	5.2 (2.4–11.2)	<0.001	——	——
Lymphovascular invasion
Presence vs. Absence	4.8 (2.6–8.9)	<0.001	4.5 (2.4–8.6)	<0.001	4.8 (2.4–9.6)	<0.001	4.7 (2.3–9.4)	<0.001
Nerve Invasion
Presence vs. Absence	4.1 (1.0–16.9)	0.050			2.7 (0.4–19.5)	0.331