Figure 1.

Chemical structure and cytotoxic activity of CCG molecules in WI-38 human lung fibroblasts. (A) CCG-203971, N-(4-Chlorophenyl)-1-[3-(2-furanyl) benzoyl]-3-piperidinecarboxamide. (B) CCG-232601, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(4-pyridinyl) benzoyl]-3-piperidinecarboxamide. (C) WI-38 cells were treated with 0.5% DMSO (vehicle control, 100% viability) and increasing concentrations of CCG molecules for 24 h and subjected to MTS cell viability assay. Graphed values are shown as the mean ± SD (n = 4), and calculated IC₅₀ values are presented as well.