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. 2024 Feb 20;25(5):2454. doi: 10.3390/ijms25052454

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

RNA-seq analysis of TNFα-treated human-induced pluripotent stem cells and neural stem progenitor cells (iPSCs-NSCs/NPCs) identifies important targets for cytokine–cytokine receptor interaction, apoptosis, and TNF signaling pathways. hiPSCs-NSCs/NPCs cells treated with or without TNFα (20 ng/mL) were used for RNA-seq analysis. (A) In the volcano plot, a total of 3556 genes were significantly differentially expressed by TNFα treatment compared to minimum media (MM) (red dots), with 1819 of them being upregulated and 1737 downregulated. (B) Tables show the top 20 upregulated (left) and downregulated (right) genes in TNFα-treated iPSCs-NSCs/NPCs. (C) The 18 most significantly enriched KEGG pathways after treatment with TNFα are shown. (D) Gene ontology analysis of the differentially expressed genes after TNFα treatment in hiPSCs-NSCs/NPCs cells. n = 5–6 sets.