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↑ concentrations of MMP-8 in periodontitis patients [93,94,96,97,98,99,100,101,102,103,104,105,106,107].
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Concentration of MMP-8 3.6 times ↑ in periodontitis patients than in healthy controls [97].
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↑ concentrations of MMP-8 in patients with more severe forms of the disease [93,99,101].
Contradictory reports on the possibility of differentiating types of periodontitis.
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Determination of MMP-8 concentrations not useful for differentiating types of periodontitis [100].
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Determination of MMP-8 is useful in differentiating serve and mild periodontitis [93].
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MMP-8 concentrations correlate with CAL, PI [97,108], increased depth of gingival pockets, and bleeding during probing [96,99,106,108].
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MMP-8 expression correlates strongly with CAL [97].
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In smokers, high levels of MMP-8 correlate with poorer response to periodontal treatment [109].
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Concentration of MMP-8 correlates with the presence of Fusobacterium nucleatum [101], Tannerella forsythia, and Treponema denticola [110].
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↓ MMP-8 levels after periodontal treatment, antibiotics, and meloxicam use [106,112,114,116].
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↓ MMP-8 levels after non-invasive hygiene methods [104,108,112,113,115].
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↑ concentrations of MMP-8 in periodontitis patients [97,99,107,116,117,118,119,132,133].
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↑ concentrations of MMP-8 in patients with more severe forms of the disease [118].
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High diagnostic power of MMP-8 in detecting periodontitis [118,119].
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MMP-8 concentrations correlate with PI [117], increased depth of gingival pockets, and bleeding during probing [99,118].
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Determination of MMP-8 concentrations is not suitable for differentiating stage of periodontitis [90].
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↓ MMP-8 levels after non-invasive hygiene methods [119].
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No change in MMP-8 levels after doxycycline therapy [121].
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No differences in MMP-8 concentrations between patients with periodontitis and healthy subjects [103].
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↑ concentrations of aMMP-8 in patients with periodontitis [124,131].
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↑ sensitivity and specificity of aMMP-8 in detecting periodontitis compared to classical diagnostic methods (conventional bleeding on probing [BOP]) [29,124,131].
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False positives in the detection with aMMP-8 of periodontitis compared to BOP [127].
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Correlation of aMMP-8 with the severity of periodontitis [128,131], PI [124], and the presence of Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia, Parvimonas micra, Camphylobacter rectus, and Eubacterium nodatum [128].
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↓ of aMMP-8 after periodontal treatment [129].
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