Table 1.
Mtb-specific proteins identified in different studies.
| SN | Total/Subproteome | Proteins | Method of Isolation | Instruments Used | Ref. |
|---|---|---|---|---|---|
| 1 | Sputum/Serum | Rv3804c-FbpA | Spectrophotometer | [72,73] | |
| 2 | Sputum/Serum | Rv1860-Apa | Ag/Ab assay | Spectrophotometer | [74] |
| 3 | Serum | Rv0440-GroEL2 | Spectrophotometer | [75] | |
| 4 | CSF/Serum | Rv1837c-GlcB, Rv2031c-HspX, Rv0934-PstS1 | Spectrophotometer | [76] | |
| 5 | Serum | Rv2244-AcpM, Rv3804c-Ag85a, Rv1886c-Ag85b, Rv0129c-Ag85c, Rv1860-Apa, Rv3841-BfrB, Rv1827-Cfp17, Rv0350-DnaK, Rv0363c-Fba, Rv1837c-GlcB, Rv3418c-GroES, Rv2031c-HspX, Rv0066c-Icd2, Rv1908c-KatG, Rv1980c-Mpt64, Rv3248c-SahH, Rv0009-PpiA | ExoQuick | LTQ linear ion trap | [19] |
| 6 | Serum | Rv0129c-Ag85c, Rv1837c-GclB, Rv1860-MPT32, Rv1980c-MPT64, Rv2031c-HspX, Rv2376c-Cfp2, Rv3248c-SahH, Rv3418c-GroES, Rv3841-BfrB, Rv0350-DnaK, Rv1886c-Ag85B, Rv3874-Cfp10, Rv3875-EsxA, Rv2220-GlnA1, Rv3441c-MrsA, Rv0009-PpiA, Rv2244-AcpM, Rv3804c-Ag85A, Rv1827-GarA | ExoQuick | Xevo TQ-S mass spectrometer | [36] |
| 7 | Plasma | Hsp16.3 | Ultracentrifugation | [71] | |
| 8 | Urine | Rv1656-ArgF, Rv3341-MetA, Rv2392-cysH | Ultrafiltration | LCQ-DECA XP | [77,78] |
| 9 | Urine | Rv1681-MoeX | LCQ-DECA XP | [79] | |
| 10 | Urine | Rv0014c-PknB, Rv2748c-FtsK, Rv1664-Pks9, Rv1161-NarG, Rv2490c-PE_PGRS43, Rv0578c-PE_PGRS7 | Ultrafiltration | LTQ-Orbitrap Velos Pro | [80] |
| 11 | H37Rv-infected J774 cells and CFP-treated J774 cells | Rv0129c-Antigen 85C, Rv0211-PckA, Rv0350-DnaK, Rv0462-LpdC, Rv0896-GltA2, Rv0934-PstS1, Rv1448-Tal, Rv1827-Cfp17, Rv1837-GlcB, Rv1860-Apa, Rv1886c-Antigen 85B, Rv1908c-KatG, Rv1926c-Mpt63, Rv1932-Tpx, Rv1980c-Mpt64, Rv2031c-HspX, Rv2220-GlnA1, Rv2244-AcpM, Rv2376c-Cfp2, Rv2467-PepN, Rv2780-Ald, Rv2878c-Mpt53, Rv3248c-SahH, Rv3418 -GroES, Rv3804c-Antigen 85A | Filtration and ultracentrifugation | LCQ DECA XP | [60] |
| 12 | Culture | Rv2244-AcpM, Rv1860-Apa, Rv1793-FadA3, Rv0363c-Fba, Rv3804c-FbpA, Rv1908c-KatG, Rv2945c-LppX, Rv3763-LpqH, Rv0040c-Mtc28, Rv1017c-Prs, Rv0934-PstS1, Rv3846-SodB, Rv1793-EsxN, Rv2220-GlnA1 | Density gradient ultracentrifugation | LTQ-Orbitrap Velos | [69] |
| 13 | Cerebrospinal fluid | Rv3875-ESAT6 | 1D-2D PAGE | Spectrophotometer | [81] |
| 14 | Cerebrospinal fluid | Rv2623-TB31.7 | Spectrophotometer | [82] |