Table 10.

Adenylyl cyclase activity in the absence (basal) and presence of NaF, forskolin and Gpp (NH)p in the right ventricle from the control as well as at early (4 weeks), moderate (8 weeks) and severe (16 weeks) stages of heart failure due to myocardial infarction (MI) in rats.

Parameters	Control	Early Failure Stage (4 Weeks MI)	Moderate Failure Stage (8 Weeks MI)	Severe Failure Stage (16 Weeks MI)
Adenylyl cyclase activity (pmol cyclic AMP/10 min/mg protein):
Basal	114 ± 15	66 ± 8 *	156 ± 8 *	163 ± 10*
NaF (5 mM)	570 ± 54	244 ± 36 *	936 ± 76 *	720 ± 31 *
Foskolin (100 μM)	353 ± 23	183 ± 22 *	624 ± 45 *	484 ± 12 *
Gpp (NH)p (30 μM)	300 ± 16	171 ± 12 *	445 ± 21 *	455 ± 9 *

Values are mean ± SE of four to six experiments. The data are based on the information in our paper, Sethi et al., 1997 [46]. * p < 0.05 vs. control.