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N1303K/2143delT, N1303K/3821delT, N1303K/G461E and F508del/F508del (control) intestinal organoid swelling upon 1 h treatment with 5 µM forskolin. Organoids were stained with Calcein AM, and each CFTR-modulator concentration is 3.5 µM; Scale bar: 500 μm.
