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. 2024 Mar 6;25(5):3049. doi: 10.3390/ijms25053049

Figure 2.

Figure 2

DNA damage and apoptosis. (A) Western blot analysis of pSer139-H2AX 24 and 48 h after DDP treatment in F3 and in Brca1−/− parental and resistant sublines. (B) Caspase 3/7 activity in F3 (blue), F3 ddpR (green), Brca1−/− (pink) and Brca1−/− ddpR (orange) cells 24, 48 and 72 h after DDP. Data are expressed as the fold increase over untreated cells and are the mean ± SD of two independent experiments. For statistical analyses, unpaired t-test was used. Only statistically significant differences are reported: * = p < 0.05; ** = p < 0.005; **** = p < 0.0001.