Table 1.

IC50 of different compounds in DDP-sensitive and -resistant HR-proficient and -deficient ID8 cells.

DRUG	F3	F3 ddpR	FI	p Value *	Brca1−/−	Brca1−/− ddpR	FI	p Value *
CISPLATIN (µM)	16.94 ± 8.26	>150	>10	p = 0.003	3.88 ± 0.86	22.05 ± 11.63	5.7	p = 0.02
CARBOPLATIN (µM)	60.67 ± 9.08	1060 ± 176.64	17.5	p = 0.015	25.2 ± 0.35	86.7 ± 1.27	3.4	p = 0.002
OXALIPLATIN (µM)	79.08 ± 17.92	212 ± 82.72	2.7	p = 0.05	14.41 ± 2.18	32.55 ± 3.56	2.1	p = 0.0078
OLAPARIB (µM)	6.44 ± 0.5	7.53 ± 3.98	1.2	p = 0.63	0.08 ± 0.002	2.05 ± 0.7	24.5	p = 0.05
RUCAPARIB (µM)	13.68 ± 2.86	5.24 ± 2.63	0.4	p = 0.0197	0.21 ± 0.1	3.58 ± 1.71	17.3	p = 0.027
NIRAPARIB (µM)	0.35 ± 0.04	0.33 ± 0.3	0.9	p = 0.93	0.04 ± 0.01	0.26 ± 0.07	7.5	p = 0.043
YONDELIS (nM)	0.8 ± 0.36	1.95 ± 0.74	2.5	p = 0.18	0.11 ± 0.02	0.57 ± 0.04	5.2	p = 0.0056
PACLITAXEL (nM)	19.72 ± 2.31	4.18 ± 1.8	0.2	p = 0.017	22.27 ± 1.9	14.8 ± 3.1	0.7	p = 0.1
DOXORUBICIN (nM)	84.62 ± 7.01	44.2 ± 0.49	0.5	p = 0.01	34.8 ± 10.7	27.65 ± 0.2	0.8	p = 0.44
KU55933 (µM)	4.06 ± 0.59	2.42 ± 0.16	0.6	p = 0.06	1.66 ± 0.77	1.11 ± 0.18	0.7	p = 0.43
AZD6738 (µM)	0.26 ± 0.07	0.83 ± 0.65	3.2	p = 0.2	0.2 ± 0.04	0.23 ± 0.11	1.2	p = 0.64
AZD1775 (µM)	0.42 ± 0.2	1.08 ± 0.69	2.6	p = 0.11	0.2 ± 0.09	0.2 ± 0.14	0.9	p = 0.76
AZD7762 (µM)	0.19 ± 0.08	0.38 ± 0.17	2	p = 0.08	0.13 ± 0.06	0.22 ± 0.15	1.7	p = 0.28
NU7741 (µM)	1.72 ± 0.11	1.34 ± 0.07	0.8	p = 0.06	2.32 ± 0.11	1.02 ± 0.29	0.4	p = 0.03

FI: fold increase. * Unpaired t test.