Table 2.
Comparison of different species’ neurotrophin (BDNF, NGF, and NT-3), and tyrosine kinase receptor (TrkA, TrkB, TrkC) localization and expression in the retina layers of N. guentheri.
| Species | N. guentheri * | Zebrafish | Mouse | Human | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Antibodies | BDNF | NGF | NT-3 | Trks | BDNF | NGF | NT-3 | Trks | BDNF | NGF | NT-3 | Trks | BDNF | NGF | NT-3 | Trks | |||||||||
| A | B | C | A | B | C | A | B | C | A | B | C | ||||||||||||||
| Cell layers | RPE | + | n/a | + | + | + | + | + | + | − | + | + | + | + | + | n/a | + | + | − | + | n/a | n/a | + | + | − |
| R. | [10,81,105,107,108,109,110,111,112] | [17,96,101] | [97,113] | ||||||||||||||||||||||
| PRL | + | + | + | + | + | + | + | + | − | + | + | + | + | + | + | + | + | + | + | n/a | n/a | + | + | + | |
| R. | [10,81,110,111,112] | [95,101,108,114] | [97,115] | ||||||||||||||||||||||
| OPL | − | − | − | − | − | − | + | + | − | + | + | + | + | n/a | + | + | − | + | + | n/a | n/a | + | + | + | |
| R. | [10,81,110,111,112] | [95,108] | [97,115] | ||||||||||||||||||||||
| INL | + | + | + | − | − | − | + | + | − | + | + | + | + | + | + | + | + | − | + | n/a | n/a | + | + | + | |
| R. | [10,81,110,111,112] | [95,108,116] | [97,115] | ||||||||||||||||||||||
| HCs | − | − | − | − | − | − | + | + | − | + | + | + | + | + | n/a | + | + | + | n/a | n/a | n/a | + | + | + | |
| R. | [10,81,110,111,112] | [95,108] | [97] | ||||||||||||||||||||||
| BCs | − | + | + | + | + | − | + | + | − | + | + | + | + | + | n/a | − | − | − | n/a | n/a | n/a | n/a | n/a | n/a | |
| R. | [10,81,110,111,112] | [95,101,108,114,116] | |||||||||||||||||||||||
| ACs | + | + | + | + | + | + | + | + | − | + | + | + | + | n/a | + | + | − | − | + | n/a | n/a | + | + | + | |
| R. | [10,110,111,112,117] | [95,108] | [97,118] | ||||||||||||||||||||||
| IPL | − | − | − | − | − | − | + | + | − | + | + | + | + | n/a | n/a | + | + | + | + | n/a | n/a | + | + | + | |
| R. | [10,81,102,110,111,112] | [95,108] | [97,119] | ||||||||||||||||||||||
| GCL | + | + | + | + | + | + | + | + | − | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | |
| R. | [10,81,102,110,111,112] | [17,95,96,107,120] | [97,121,122,123] | ||||||||||||||||||||||
(*) these data refer to the sample of the present study. (+) positive for the considered antibody; (−) negative for the considered antibody; (n/a) references data not known, to the best of the authors’ knowledge. References (R.), Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3), tyrosine protein kinase receptors type A (TrkA), tyrosine protein kinase receptors type B (TrkB), tyrosine protein kinase receptors type C (TrkC), retinal pigment epithelium (RPE), photoreceptor layer (PRL), outer nuclear layer (ONL), outer plexiform layer (OPL), inner nuclear layer (INL), amacrine cells (ACs), bipolar cells (BCs), horizontal cells (HCs), inner plexiform layer (IPL), ganglion cell layer (GCL).