Table 3.
The allele and genotype frequency of the common polymorphisms located in key DNA double-strand break repair-related genes in control and rheumatoid arthritis (RA) groups.
| Polymorphism/Gene | Genotype | Control | RA | OR (95% CI) |
|---|---|---|---|---|
| rs3218536/XRCC2 | C/C | 3 (6.7%) | 1 (2.2%) | 1.00 |
| C/T | 41 (91.1%) | 43 (95.6%) | 3.15 (0.31–31.49) | |
| T/T | 1 (2.2%) | 1 (2.2%) | 3.00 (0.08–107.45) | |
| rs1801320/RAD51 | G/G | 32 (71.1%) | 19 (40.0%) | 1.00 |
| G/C | 2 (4.4%) | 8 (17.8%) | 6.74 (1.29–35.08) | |
| C/C | 11 (24.4%) | 18 (42.2%) | 2.75 (1.07–7.06) | |
| rs7180135/RAD51 | G/G | 5 (11.1%) | 4 (8.9%) | 1.00 |
| A/G | 22 (48.9%) | 31 (68.9%) | 1.76 (0.42–7.31) | |
| A/A | 18 (40%) | 10 (22.2%) | 0.69 (0.15–3.19) | |
| rs45549040/RAD51 | A/A | 41 (91.1%) | 43 (95.6%) | 1.00 |
| A/C | 3 (6.7%) | 0 (0%) | 0.00 (0.00–NA) | |
| C/C | 1 (2.2%) | 2 (4.4%) | 1.91 (0.17–21.84) | |
| rs1801321/RAD51 | G/G | 17 (37.8%) | 7 (15.6%) | 1.00 |
| G/T | 9 (20%) | 11 (24.4%) | 2.97 (0.85–10.31) | |
| T/T | 19 (42.2%) | 27 (60%) | 3.45 (1.20–9.94) | |
| rs2619681/RAD51 | C/C | 30 (66.7%) | 30 (66.7%) | 1.00 |
| C/T | 13 (28.9%) | 13 (28.9%) | 1.00 (0.40–2.51) | |
| T/T | 2 (4.4%) | 2 (4.4%) | 1.00 (0.13–7.57) | |
| rs963917/RAD51B | G/G | 12 (26.7%) | 26 (57.8%) | 1.00 |
| A/G | 23 (51.1%) | 17 (37.8%) | 0.34 (0.13–0.86) | |
| A/A | 10 (22.2%) | 2 (4.4%) | 0.09 (0.02–0.49) | |
| rs963918/RAD51B | C/C | 7 (15.6%) | 5 (11.1%) | 1.00 |
| C/T | 17 (37.8%) | 26 (57.8%) | 2.14 (0.58–7.86) | |
| T/T | 21 (46.7%) | 14 (31.1%) | 0.93 (0.25–3.54) | |
| rs3784099/RAD51B | G/G | 30 (66.7%) | 20 (44.4%) | 1.00 |
| A/G | 11 (24.4%) | 23 (51.1%) | 3.14 (1.26–7.83) | |
| A/A | 4 (8.9%) | 2 (4.4%) | 0.75 (0.13–4.49) | |
| rs10483813/RAD51B | T/T | 34 (75.6%) | 33 (73.3%) | 1.00 |
| A/T | 8 (17.8%) | 11 (24.4%) | 1.42 (0.51–3.96) | |
| A/A | 3 (6.7%) | 1 (2.2%) | 0.34 (0.03–3.47) | |
| rs1042522/TP53 | C/C | 21 (46.7%) | 26 (57.8%) | 1.00 |
| C/G | 11 (24.4%) | 14 (31.1%) | 1.03 (0.39–2.73) | |
| G/G | 13 (28.9%) | 5 (11.1%) | 0.31 (0.10–1.01) | |
| rs1051669/RAD52 | C/C | 31 (68.9%) | 25 (55.6%) | 1.00 |
| C/T | 14 (31.1%) | 19 (42.2%) | 1.68 (0.71–4.01) | |
| T/T | 0 (0%) | 1 (2.2%) | NA (0.00-NA) | |
| rs2155209/MRE11A | T/T | 15 (33.3%) | 15 (33.3%) | 1.00 |
| C/T | 19 (42.2%) | 26 (57.8%) | 1.37 (0.54–3.46) | |
| C/C | 11 (24.4%) | 4 (8.9%) | 0.36 (0.09–1.40) | |
| rs132774/XRCC6 | G/G | 20 (44.4%) | 16 (35.6%) | 1.00 |
| C/G | 13 (28.9%) | 18 (40%) | 1.73 (0.66–4.57) | |
| C/C | 12 (26.7%) | 11 (24.4%) | 1.15 (0.40–3.27) | |
| rs207906/XRCC5 | G/G | 33 (73.3%) | 29 (64.4%) | 1.00 |
| A/G | 8 (17.8%) | 12 (26.7%) | 1.71 (0.61–4.75) | |
| A/A | 4 (8.9%) | 4 (8.9%) | 1.14 (0.26–4.96) | |
| rs7003908/PRKDC | A/A | 14 (31.1%) | 10 (22.2%) | 1.00 |
| A/C | 27 (60%) | 25 (55.6%) | 1.30 (0.49–3.44) | |
| C/C | 4 (8.9%) | 10 (22.2%) | 3.50 (0.85–14.41) | |
| rs861539/XRCC3 | G/G | 33 (73.3%) | 39 (86.7%) | 1.00 |
| A/G | 4 (8.9%) | 1 (2.2%) | 0.21 (0.02–1.99) | |
| A/A | 8 (17.8%) | 5 (11.1%) | 0.53 (0.16–1.77) |
Bold indicates statistically significant results; NA—not determined.