Table 2.

Univariate and multivariate analyses of sTILs and their association with pathological response.

	sTILs Continuous Variable				sTILs Stratified Variable
	Univariate Analyses		Multivariate Analyses *		Univariate Analyses		Multivariate Analyses *
	OR (95% CI )	p	OR (95% CI )	p	OR (95% CI )	p	OR (95% CI )	p
pCR	1.22 [1.05; 1.42]	0.010	1.20 [1.00; 1.43]	0.046	4.46 [1.35; 14.80]	0.011	3.73 [1.01; 13.74]	0.048
MPbreast	1.18 [1.04; 1.34]	0.013	1.17 [1.02; 1.35]	0.027	2.62 [1.16; 5.96]	0.022	2.45 [1.02; 5.88]	0.045
MPaxilla	1.05 [0.93; 1.19]	0.458			1.46 [0.70; 3.05]	0.324
RCB	1.11 [0.98; 1.26]	0.110			1.43 [0.69; 2.95]	0.333

sTILs: stromal tumour-infiltrating lymphocytes, pCR: pathological complete response, MP: Miller and Payne, RCB: residual cancer burden, OR: odds ratio, CIs: confidence intervals. sTILs stratified variable: high-TILs (>10%) vs. low-TILs (≤10%); Responders: pCR ypT0/is ypN0, MP-4/5 and MP-A/D, and RCB 0; Non-responders: non-pCR, MP-1/2/3 and MP-B/C, and RCB I/II and III. * The multivariate analyses included histological grade (G3 vs. G1/G2), tumour size (T2/T3/T4 vs. T1), lymph node status (N+ vs. N0), and molecular subtype (luminal-A, luminal-B, TNBC) as covariates. The statistical parameters shown in the table refer to sTILs (continuous and stratified variables). Statistically significant p-values are marked in bold.