Table 5.

Univariate and multivariate analyses of the clusters identified by unsupervised hierarchical clustering analysis and their association with pathological responses.

	Entire Cohort (C1 vs. C2)				Luminal-B (C3 vs. C4)
	Univariate Analyses		Multivariate Analyses *		Univariate Analyses		Multivariate Analyses *
	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
MPbreast	0.31 [0.11; 0.83]	0.024	0.36 [0.13; 1.03]	0.057	0.21 [0.05; 0.91]	0.046	0.15 [0.03–0.77]	0.023
MPaxilla	0.56 [0.20; 1.53]	0.265			0.18 [0.03; 0.95]	0.039	0.10 [0.01–0.70]	0.020
pCR	0.36 [0.11; 0.15]	0.103			0.69 [0.11; 4.24]	0.691
RCB	0.46 [0.18; 1.20]	0.113			0.40 [0.10; 1.58]	0.193

MP: Miller and Payne, pCR: pathological complete response, RCB: residual cancer burden, OR: odds ratio, CIs: confidence intervals. * The multivariate analyses included histological grade (G3 vs. G1/G2), tumour size (T2/T3/T4 vs. T1), lymph node status (N+ vs. N0) for Luminal-B, and also molecular subtype (luminal-A, luminal-B, TNBC) for the entire cohort. Statistically significant p-values are marked in bold.