Table 4.
Results of Kruskal–Wallis H test for significant differences between multiple groups. Twenty-seven differentially expressed RNAs were found to be upregulated in the plasma of CRC patients.
| Gene Name | Refseq | Stage I | Stage II | Stage III | Stage IV | Normal | p-Value | Adjusted p-Value * |
|---|---|---|---|---|---|---|---|---|
| BANK1 | NM_001083907.1 | 3118.818 | 3773.453 | 3697.386 | 944.5667 | 169.1133 | 0.001758 | 0.004394 |
| BGN | NM_001711.3 | 103.0225 | 191.175 | 149.2763 | 123.5811 | 20 | 0.002165 | 0.004639 |
| CDA | NM_001785.2 | 82,333 | 133,665.2 | 79,813.29 | 30,877.19 | 41,917.4 | 0.03538 | 0.04746 |
| CEACAM7 | NM_006890.4 | 46.1025 | 51.425 | 13,521.77 | 28.64333 | 20 | 0.010153 | 0.016922 |
| CEMIP | NM_018689.1 | 47,200.59 | 59,372.89 | 23,834.92 | 18,151.22 | 4046.548 | 0.025741 | 0.035781 |
| CTNNB1 | NM_001098210.1 | 15,716.63 | 36,968.89 | 25,861.48 | 19,006.47 | 8143.892 | 0.003437 | 0.006751 |
| CTSL | NM_001912.4 | 26,001.42 | 36,041.48 | 22,480.74 | 15,920.57 | 3366.493 | 0.003889 | 0.00713 |
| EPAS1 | NM_001430.3 | 283.21 | 3203.148 | 3505.034 | 1865.092 | 1235.516 | 0.024221 | 0.035057 |
| FAM129C | NM_173544.4 | 58,697.87 | 99,605.14 | 59,054.28 | 47,203.52 | 16,909.75 | 0.000818 | 0.002248 |
| FAP | NM_004460.2 | 321.02 | 102.3725 | 869.8074 | 46.50889 | 20 | 0.002193 | 0.004639 |
| GK | NM_000167.3 | 19,534.83 | 29,865.46 | 20,696.59 | 10,550.17 | 3633.967 | 0.010934 | 0.017687 |
| GUCY2C | NM_004963.1 | 61.775 | 97.025 | 494.8544 | 68.26778 | 20 | 0.002057 | 0.004639 |
| INHBA | NM_002192.2 | 50,134.49 | 86,119.04 | 54,501 | 47,530.9 | 18,310.55 | 0.004839 | 0.008317 |
| KRT19 | NM_002276.4 | 12,402.46 | 32,193.63 | 26,178.84 | 29,384.17 | 4029.44 | 0.00057 | 0.001669 |
| KRT20 | NM_019010.2 | 46,344.5 | 11,6612.9 | 78,925.36 | 56,187.71 | 10,225.4 | 0.001336 | 0.003498 |
| MKI67 | NM_002417.2 | 56,987.24 | 74,004.38 | 77,026.36 | 52,881.03 | 22,054.26 | 0.026023 | 0.035781 |
| MMP7 | NM_002423.4 | 3649.235 | 277.8825 | 382.3 | 120.2722 | 20 | 0.00052 | 0.001669 |
| MMP9 | NM_004994.2 | 367.665 | 6548.393 | 7647.711 | 3684.182 | 20 | 0.000296 | 0.001086 |
| MS4A1 | NM_152866.2 | 18,589.93 | 22,468.3 | 17,110.81 | 7012.719 | 650.3958 | 0.000195 | 0.000893 |
| MYC | NM_002467.4 | 13,616.51 | 34,941.22 | 27,283.9 | 26,276.21 | 5521.895 | 0.003054 | 0.006222 |
| PIP4K2B | NM_003559.4 | 308.945 | 6175.323 | 1391.916 | 1687.758 | 20 | 0.002117 | 0.004639 |
| PLAUR | NM_002659.3 | 565.765 | 12,562.74 | 6378.578 | 9516.01 | 1035.063 | 0.003746 | 0.007105 |
| PTGS2 | NM_000963.3 | 27,295.66 | 20,618.94 | 25,963.25 | 16,800.94 | 20 | 0.004645 | 0.008242 |
| S100A4 | NM_019554.2 | 33,689 | 44,015.95 | 37,234.61 | 25,325.74 | 18,203.82 | 0.012145 | 0.019084 |
| TRIM24 | NM_015905.2 | 592.65 | 8514.685 | 7197.833 | 3787.37 | 20 | 0.0000283 | 0.000398 |
| TUG1 | NR_002323.1 | 975.32 | 5631.128 | 8363.993 | 21,629.69 | 2689.192 | 0.014668 | 0.021804 |
| TYMS | NM_001071.2 | 30,818.32 | 50,162.11 | 39,236.93 | 33,363.06 | 13,571.37 | 0.013251 | 0.020245 |
* adjusted p-value using the Benjamini–Hochberg procedure.