Figure 3.

Interaction between virus and host within the oral cavity. Clearance of oral HPV infection may be similar to that of anogenital HPV infections in healthy populations. The spontaneous resolution aligns with the titers of antibodies against HPV and is more frequent in case of an LR-HPV contamination. Conversely, the persistence of the infection into the oral cavity-which is often subclinical–is more frequently associated with high-risk HPV (HR-HPV) genotypes and is the major risk factor for disease progression and oral dysplasia.