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. 2024 Mar 2;25(5):2929. doi: 10.3390/ijms25052929

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The multifaceted role of neutrophils in the tumor microenvironment: Neutrophils can act as both pro-tumorigenic and anti-tumorigenic, employing various functions depending on the disease stage and their location (as described in detail in the text). ROS-Reactive Oxygen Species; DNA-Deoxyribonucleic acid; IL1Ra-Interleukine-1 Receptor Alpha; NK cells-Natural Killer Cells; SIRPa- Signal Regulatory Protein alpha; MHCII- Major Histocompatibility complex II; PGE1-Prostaglandin E1; TRAIL/FasL-Tumor Necrosis Factor-Related Apoptosis Inducing Ligand/Fas Ligand; NO-Nitric Oxide; Arg- Arginase; PDL1-Programmed death-ligand 1; MMP- Matrix metalloproteinases; MPO-Myeloperoxidase; FcRs- Fc receptors. Created with BioRender.com (accessed on 25 January 2024).