Figure 1.

Cluster analysis of neuropathologic scores between α-synuclein high and low seeders. Neuropathologic scores of neuronal loss, α-synuclein, phosphorylated tau, and Aβ in the substantia nigra (A). α-Synuclein semiquantitative scores across the brain, Braak NFT and LBD stages, and Thal phases (B). The darker color represents the higher semiquantitative scores. Abbreviations: Aβ: amyloid beta; DMNV: dorsal motor nucleus of the vagus; HS: high seeder; LS: low seeder; NFT: neurofibrillary tangle; pTau: phosphorylated tau.