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. 2024 Feb 23;25(5):2594. doi: 10.3390/ijms25052594

Table 1.

Proteins significantly altered in tissues by NMN treatment.

Tissue Protein Name/Pathway Function Expression Change
Liver Nolc1 Ribosome biogenesis Downregulated
Liver Clic4 Regulation of extracellular matrix production Downregulated
Liver Mt-Cyb Improves the electron carrier function of mitochondria Upregulated
Liver FTH1 Iron storage and homeostasis Upregulated
Liver
Muscle NUP210L Transport of macromolecules between the nucleus and cytoplasm Upregulated
Muscle Cep43 Regulation of microtubule dynamics and spindle formation during mitosis Upregulated
Muscle VNN1 Regulation of oxidative stress and inflammation Upregulated
Muscle CDC27 Regulation of the cell cycle Upregulated
Muscle TRAPPC3L transport of proteins between the endoplasmic reticulum (ER) and Golgi apparatus Upregulated
Muscle GLUT4 Glucose internalization in muscle cells Downregulated
Muscle UCP1 Thermogenesis Upregulated
Adipose mTOR pathway Cell growth Upregulated
Adipose Lysosomal pathway Lipid metabolism Upregulated
Adipose Resistin Adipokine involved in insulin resistance Downregulated
Brain OXPHOS proteins Mitochondrial function Downregulated
Brain Tight Junctions Cell membrane structure Upregulated
Brain ABCB10 Regulation of mitochondrial function in neurons Downregulated
Brain Synaptic plasticity proteins Neuronal survival and development Upregulated
Brain HMGCS2 Ketone bodies synthesis Upregulated
Brain Ube2z Improved turnover of synaptic proteins Upregulated

Nolc1—nucleolar and coiled-body phosphoprotein 1; Clic4—chloride intracellular channel 4; Mt-Cyb—mitochondrially encoded cytochrome B protein; FTH1—ferritin heavy polypeptide 1; NUP210L—nucleoporin 210-like; CEP43—centrosomal protein 43; VNN1—vanin 1; CDC27—cell division cycle 27; TRAPPC3L –trafficking protein particle complex 3-like; GLUT4—glucose transporter type 4; UCP1—uncoupling protein 1; ABCB10—ATP-binding cassette sub-family B member 10; HMGCS2—3-hydroxy-3-methylglutaryl-coenzyme A synthase 2; Ube2z—ubiquitin-conjugating enzyme E2Z.