Table 1.
Tissue | Protein Name/Pathway | Function | Expression Change |
---|---|---|---|
Liver | Nolc1 | Ribosome biogenesis | Downregulated |
Liver | Clic4 | Regulation of extracellular matrix production | Downregulated |
Liver | Mt-Cyb | Improves the electron carrier function of mitochondria | Upregulated |
Liver | FTH1 | Iron storage and homeostasis | Upregulated |
Liver | |||
Muscle | NUP210L | Transport of macromolecules between the nucleus and cytoplasm | Upregulated |
Muscle | Cep43 | Regulation of microtubule dynamics and spindle formation during mitosis | Upregulated |
Muscle | VNN1 | Regulation of oxidative stress and inflammation | Upregulated |
Muscle | CDC27 | Regulation of the cell cycle | Upregulated |
Muscle | TRAPPC3L | transport of proteins between the endoplasmic reticulum (ER) and Golgi apparatus | Upregulated |
Muscle | GLUT4 | Glucose internalization in muscle cells | Downregulated |
Muscle | UCP1 | Thermogenesis | Upregulated |
Adipose | mTOR pathway | Cell growth | Upregulated |
Adipose | Lysosomal pathway | Lipid metabolism | Upregulated |
Adipose | Resistin | Adipokine involved in insulin resistance | Downregulated |
Brain | OXPHOS proteins | Mitochondrial function | Downregulated |
Brain | Tight Junctions | Cell membrane structure | Upregulated |
Brain | ABCB10 | Regulation of mitochondrial function in neurons | Downregulated |
Brain | Synaptic plasticity proteins | Neuronal survival and development | Upregulated |
Brain | HMGCS2 | Ketone bodies synthesis | Upregulated |
Brain | Ube2z | Improved turnover of synaptic proteins | Upregulated |
Nolc1—nucleolar and coiled-body phosphoprotein 1; Clic4—chloride intracellular channel 4; Mt-Cyb—mitochondrially encoded cytochrome B protein; FTH1—ferritin heavy polypeptide 1; NUP210L—nucleoporin 210-like; CEP43—centrosomal protein 43; VNN1—vanin 1; CDC27—cell division cycle 27; TRAPPC3L –trafficking protein particle complex 3-like; GLUT4—glucose transporter type 4; UCP1—uncoupling protein 1; ABCB10—ATP-binding cassette sub-family B member 10; HMGCS2—3-hydroxy-3-methylglutaryl-coenzyme A synthase 2; Ube2z—ubiquitin-conjugating enzyme E2Z.