Table 1.
Information on the induced-pluripotent stem cells (iPSC) lines used. All donor lines are Caucasian. APOE genotype is shown in the table because it is the main non-autosomal dominant AD risk gene. APOE ε3 is the most common allele and is considered neutral in terms of AD risk, while APOE ε2 is associated with a reduced risk of developing the disease, and APOE ε4 is linked to an increased risk, compared to APOE ε3.
| iPSC Line | Genotype | Sex | APOE Genotype |
|---|---|---|---|
| F12455 | APP and PSEN1 mutation Negative | F | 3/3 |
| F15553.3 | APP V717L Positive | M | 3/3 |
| F16574.1 | APP V717I Positive | M | 3/3 |
| FA12462 | APP V717I Negative | M | 3/3 |
| F12424.2 | PSEN1 A79V Positive | M | 3/4 |
| F12436.2 | PSEN1 A79V Negative | M | 3/3 |
| F12434.1 | PSEN1 G217R Positive | M | 2/4 |
| F12445.5 | PSEN1 G217R Negative | F | 3/4 |