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The antidepressant‐like effect of chronic FLX was blocked in Flk‐1 NEURON−/− mice. (A) Experimental timeline. The effect of forebrain excitatory neuron‐specific knockout of Flk‐1 on the antidepressant‐like effect of chronic FLX in the preswim (B; interaction, F 1, 19 = 5.97, P = 0.0245, two‐way ANOVA, n = 5–7) and FST (C; interaction, F 1, 19 = 14.6, P = 0.0012, two‐way ANOVA, n = 5–7). Data are expressed as means ± SEM. *P < 0.05, **P < 0.01 (Tukey's post hoc test).
