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The sequences of PEK are related to eIF-2α kinases. Shown is a sequence alignment of the kinase catalytic domains of rat PEK, human PKR, rat HRI, and yeast GCN2 generated by the program Pileup. Identical amino acid residues of the eIF-2α kinases are designated by black boxes, and gaps in the alignment are indicated by dashes. Kinase subdomains are highlighted by bars above the multisequence alignment.
