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. 2024 Feb 28;15:1308217. doi: 10.3389/fphar.2024.1308217

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Copyright © 2024 Lee, Coles and Maynes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of functional similarities and differences between iPSC-CMs and adult human CMs (ACM). iPSC-CMs are similar in many aspects including electrophysiology, calcium handling, contractile machinery which allows the use of iPSC-CMs to predict cellular responses to novel compounds. However, there are some differences that must be considered when considering iPSC-CMs as a model for cardiotoxicity testing. Some of these differences include ion channel kinetics, upstroke velocities, structural differences in the contractile machinery, isoform of proteins, and metabolic function. TTCC: T-type calcium channel, LTCC: L-type calcium channel, hERG: human-ether-a-go-go (rapid delayed rectifier potassium channel), Kv7.1: slow delayed rectifier postassium channel, NCX: sodium calcium exchanger, HCN: hyperpolarization-activated cyclic nucleotide gated channel, K_v4.2, 4.3, 1.4: voltage dependent potassium channels responsible for the transient outward current, AR: adrenergic receptor, RyR2: ryanodine receptor, SERCA2a: sarcoendoplasmic reticulum calcium ATPase, PLN: phospholamban, Oxphos: oxidative phosphorylation, MHC: myosin heavy chain. Created with www.biorender.com.