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Predicted μ-opioid receptor occupancy by fentanyl after peak fentanyl plasma concentrations of 50 ng/mL (A) 75 ng/mL (B) and 100 ng/mL (C). IM, intramuscular. Naloxone was given at time 0, and receptor occupancy was simulated based on known pharmacokinetic parameters of IM naloxone. Dashed gray line marks 50% receptor occupancy. Redrawn from Moss et al. (41) ©2022, Ronald B. Moss, This is an open access article distributed under the Creative Commons Attribution License (CC BY).
