TABLE 4.

Concordance of qHTS KS, SPE–MS/MS DPRA-C/K, IL-8 HTRF, and CD86/CD54 surface expression assays (based on OECD TG criteria) and OECD Toolbox automated workflow predictions for 288 chemicals. The compounds detected as active and inactive were counted separately. The gray area is for concordance of compounds detected as active in assays. The blue area is for concordance of compounds detected as inactive in assays.

OECD TG criteria	Number of chemicals detected as active in assays
Method	qHTS KS (143)	SPE–MS/MS DPRA-C/K (146)	CD86/CD54	IL-8 HTRF (81)	OECD TB*(174)
qHTS KS (145)		84	11	45	96
SPE–MS/MS DPRA-C/K (131)	80		14	52	100
CD86/CD54 (239)	130	123		6	11
IL-8 HTRF (207)	109	105	177		51
OECD TB*(32)	21	18	27	26
	Number of chemicals detected as inactive in assays

*71 out of domain chemicals are not included.