Table 1.

Central composite design and responses for spray drying process

Trials	Independent variables		Dependent variable
	Flow rate (mL/min)	Inlet temperature (°C)	Powder yield (%)
1	22.50	180.00	44.89
2	10.13	128.79	48.12
3	22.50	150.00	27.84
4	5.00	150.00	53.31
5	22.50	120.00	8.18
6	22.50	150.00	36.58
7	10.13	171.21	50.86
8	22.50	150.00	28.74
9	34.87	171.21	1.00
10	40.00	150.00	0.50
11	22.50	150.00	28.34
12	22.50	150.00	29.46
13	34.87	128.79	0.20