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. 2024 Mar 12;10:21. doi: 10.1038/s41523-024-00626-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The figure summarizes different clinical situations in which ctDNA is currently being exploited or might be exploited in the near future for the treatment of metastatic breast cancer: a treatment selection; b treatment switch; c detection of emerging resistance mechanisms; d prediction of complex phenotypes; e integration of ctDNA dynamics with imaging response criteria.