Table 1.

Dosage-dependent effects of the top four GWAS signals for coffee and tea intake

SNP	Nearest Gene(s)	A1/A2	Trait	N	Freq_A1	beta	s.e.	P
rs4410790	AHR	T/C	CI	421947	0.366	−0.062	0.002	1.1E-166
			MCI	393101	0.369	−0.067	0.005	5.0E-36
			HCI	124890	0.369	−0.200	0.010	5.3E-92
			TI	440094	0.367	−0.045	0.002	4.1E-92
			MTI	351508	0.373	0.034	0.006	3.4E-08
			HTI	155936	0.354	−0.091	0.007	4.9E-35
rs2472297	CYP1A1	T/C	CI	421947	0.265	0.074	0.002	2.6E-198
			MCI	393101	0.263	0.080	0.006	1.2E-40
			HCI	124890	0.264	0.250	0.010	4.8E-130
			TI	440094	0.264	0.060	0.002	1.9E-134
			MTI	351508	0.258	−0.027	0.007	9.2E-05
			HTI	155936	0.278	0.124	0.008	1.3E-54
rs1264377	PSORS1C3, MIR877	A/G	CI	421947	0.182	0.015	0.0028	4.0E-08
			MCI	393101	0.181	−0.004	0.0067	0.51
			HCI	124890	0.185	0.043	0.0119	3.5E-04
			TI	440094	0.182	−0.002	0.0028	0.37
			MTI	351508	0.181	−0.054	0.0077	2.8E-12
			HTI	155936	0.185	−0.028	0.0091	1.8E-03
rs977474	PRH1/ PPR4/TAS2R14	C/T	CI	419168	0.166	0.022	0.0029	1.8E-13
			MCI	390497	0.165	0.044	0.0071	4.6E-10
			HCI	124071	0.163	0.077	0.0125	7.1E-10
			TI	437186	0.165	−0.021	0.0029	4.0E-13
			MTI	349186	0.166	−0.058	0.0080	6.3E-13
			HTI	154901	0.167	−0.067	0.0095	1.2E-12

rs4410790 and rs2472297 are the top two GWAS signals in all GWAS except for MTI, and rs1264377 and rs977474 are the top two GWAS signals in MTI GWAS. A1/A2: minor allele/major allele. Freq_A1 allele frequency of A1, N sample size, beta estimate of SNP effect, s.e. Standard error of the beta estimate.