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. 2024 Jan 23;25(3):1541–1569. doi: 10.1038/s44319-023-00051-z

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Figure EV2 — (A) Infographic for murine MHV68 infection models used in this study. (B) Overlap of upregulated murine circRNA detected by bulk RNA-Seq from MHV68 de novo infection (NIH 3T3, n = 2) and drug-induced reactivation (HE-RIT, n = 2). (C) Heatmaps for upregulated murine circRNAs, plotted as circRNA counts (log₂FC), Gene counts (log₂FC), or CIRCScore (circFPB/linearFPB). Bulk RNA-Seq data was normalized to ERCC spike-in controls. Log₂FC is relative a paired uninfected or uninduced control. Differential expression p-values were calculated using RankProd non-parametric permutation tests. DECs were those with raw back splice junction (BSJ) count across the sample set >10, log₂FC > 0.5, and p-value < 0.05. Heatmap values are the average of biological replicates.