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. 2024 Feb 8;25(3):1022–1054. doi: 10.1038/s44319-024-00075-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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(A) Experimental design to dissect TGFβ-regulated genes in CCA cells and LINC00313 expression in HuCCT1 and Huh28 in response to TGFβ1, as identified by gene expression profiling. (B) LINC00313 expression in response to TGFβ1 stimulation for 16 h, in normal human cholangiocytes (NHC) and CCA cell lines. (C) LINC00313 expression in response to the indicated doses of TGFβ1 in HuCCT1 and Huh28 cell lines. (D) LINC00313 expression in response to TGFβ1 for the indicated time periods in HuCCT1 and Huh28 cell lines. (E) MALAT1, RNU48, GAPDH and LINC00313 RNA levels in nuclear and cytoplasmic fractions of HuCCT1 and Huh28 cell lines. Data information: Data in graphs are presented as mean ± SD (n = 3 biological replicates). *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 (Student’s t-test), n.s. not significant. Source data are available online for this figure.