Table 4.
Summary of Huntington’s disease-on-chips
| Huntington’s disease-on-chips | ||||||
|---|---|---|---|---|---|---|
| Neuropathogenesis | Chip model | Ref. Fig. | ||||
| Targeted pathogenesis | Cell source | Modelling approach | Feature | Type | Design | |
| mHTT toxicity | pCoNeu/StrNeu | mHTT (548-17q r118k) | 2D/S/C | Corticostriatal on-a-chip | 3CHRs/MCs | 507 Fig. 2n |
| Corticostriatal network dysfunction | pCoNeu/StrNeu | mHTT (140 CAG repeat) | 2D/S/C/G | Corticostriatal on-a-chip | 3CHRs/unilateral MCs | 508 |
| Corticostriatal atrophy | pCoNeu/StrNeu | mHTT (97CAG full-length) | 2D/S/C | Corticostriatal on-a-chip | 2CHRs/MCs | 509 Fig. 2m |
C closed, CHR chamber, G gradient, MC microchannel, mHTT mutant Huntingtin protein, pCoNeu primary cortical neuron, S static, StrNeu striatal neuron.