Table 2.
Demographic and Clinical Characteristics of Patients with and without Hospital-Acquired Carbapenemase-Producing Organisms (CPOs) During Initial Months of an Outbreak, Long-Term Acute-Care Hospital A (LTACH A), Florida, July 13–December 7, 2017
| Characteristic | No CPO (n=76), No. (%) a |
Any CPO (n=22), No. (%) a |
P Value |
bla
VIM
b
(n=6), No. (%) a |
P Value |
bla
KPCb
(n=20), No. (%) a |
P Value |
|---|---|---|---|---|---|---|---|
| Sex, male | 37 (48) | 12 (55) | .628 | 3 (50) | .979 | 10 (50) | .959 |
| Age, median y (IQR) | 67 (59–73) | 66 (55–72) | .874 | 71 (65–80) | .581 | 66 (59–71) | .957 |
| LOS, median (IQR) | 32 (23–50) | 43 (34–58) | .190 | 46 (39–62) | .373 | 43 (35–58) | .121 |
| Any ICU stay at LTACH A | 14 (18) | 6 (27) | .364 | 1 (17) | .814 | 6 (30) | .233 |
| Duration to first positive or last negative swab, median d (IQR) | 30 (21–42) | 29 (23–41) | .392 | 22 (20–32) | .097 | 31 (24–41) | .813 |
| Negative colonization swab(s), median (IQR) | 3 (2–3) | 1 (1–2) | <.001 | 2 (1–2) | .002 | 1 (1–2) | <.001 |
| Location at time of first positive or last negative swab | |||||||
| Unit A | 31 (41) | 8 (36) | .814 | 3 (50) | .691 | 6 (30) | .510 |
| Unit B | 37 (49) | 11 (50) | 1 (17) | 3 (15) | |||
| ICU | 31 (41) | 8 (36) | 2 (33) | 11 (55) | |||
| Oral vancomycin | 4 (5) | 4 (18) | .051 | 2 (33) | .020 | 4 (20) | .030 |
| Device(s) present at time of or before incident specimen collection | |||||||
| BiPAP/CPAP | 10 (13) | 2 (9) | .608 | 0 (0) | .342 | 2 (10) | .731 |
| Feeding tube | 61 (80) | 21 (95) | .090 | 6 (100) | .264 | 19 (95) | .124 |
| Hemodialysis vascular access device | 19 (25) | 9 (41) | .146 | 2 (33) | .790 | 9 (45) | .068 |
| Mechanical ventilation | 34 (45) | 13 (59) | .235 | 5 (83) | .073 | 12 (60) | .227 |
| PICC line | 30 (40) | 15 (68) | .017 | 4 (67) | .293 | 14 (70) | .015 |
| Tracheostomy | 34 (45) | 14 (64) | .118 | 6 (100) | .010 | 12 (60) | .269 |
| ≥3 indwelling devices c | 31 (41) | 17 (77) | .003 | 6 (100) | .010 | 15 (75) | .009 |
Note. VIM, Verona-integron-encoded metallo-β-lactamase; KPC, Klebsiella pneumoniae carbapenemase; LOS, length of stay; ICU, intensive care unit; BiPAP/CPAP, bilevel/continuous positive airway pressure; PICC, peripherally inserted central catheter. P values were calculated using the Pearson χ 2 test for categorical variables and the Welch unequal variance t test for continuous variables.
Units unless otherwise specified.
4 patients had both VIM and KPC detected; referent group for VIM is no VIM detection; referent group for KPC is no KPC detection.
Device cutoff was determined a priori.