Fig. 10.

NODDI parameter estimates. Top) z-maps for the difference between WMH and normally appearing white matter with the assumption $d_{intra}=d_{extra}=D=1.7\frac{\mu m^2}{ms}$. Middle) The same maps with the assumption $d_{intra}=d_{extra}=D=2.5\frac{\mu m^2}{ms}$. Bottom) Scatter plot of the z-values for the two cases. The results show the assumed fixed value for the diffusivity significantly affects the estimated change between WMH and normal tissue for $f_{iso}$ and $ODI$. However, the observed decrease in $f_{intra}$ is fairly robust to the difference in diffusivities, and this is inline with the results from BENCH.