TABLE 5.

List of toxicological studies with the NF.

Reference	Type of study	Test system	Max dose
Harke (2020), unpublished	Bacterial reverse mutation test OECD TG 471 (OECD, 2020), GLP	S. Typhimurium TA98, TA100, TA102, TA1535 and TA1537	Up to 5000 μg/plate (absence and presence of S9 mix)
Kadam (2022), unpublished	In vitro micronucleus test OECD TG 487 (OECD, 2016a) not in compliance with GLP	CHO‐k1 cells	2000 μg NF/mL
Kadam (2023), unpublished	In vitro micronucleus test OECD TG 487 (OECD, 2023), GLP	CHO‐k1 cells	2000 μg NF/mL
Kumar (2020), unpublished	In vivo mammalian erythrocyte micronucleus test OECD TG 474 (OECD, 2016b), GLP	Swiss Albino Mice	2000 mg NF/kg bw per day (oral gavage)
Saravanan (2020), unpublished	90‐day subchronic toxicity study OECD TG 408 (OECD, 2018) not in compliance with GLP	Sprague Dawley rats	2000 mg NF/kg bw per day
Zhao et al. (no date), unpublished	Gastrointestinal tolerability	Sprague Dawley, adult male rats	150 mg a /kg bw per day

Abbreviations: CHO, Chinese hamster ovary; GLP, Good Laboratory Practice; NF, novel food; OECD TG, Organisation for Economic Co‐operation and Development for testing of chemicals.

^a Elemental magnesium from Mg l‐threonate (corresponding to ~ 1800 mg/kg bw per day).