Skip to main content
. 2024 Feb 16;25(3):1629–1636. doi: 10.1021/acs.biomac.3c01187

Scheme 1. Detection of Amplified DNA via Electrostatically Induced Bridging Flocculation of a Cationic Polymer Latex.

Scheme 1

DNA can be extracted directly and amplified via conventional PCR. The addition of amplified DNA to a sterically-stabilized PEGMA-P2VP latex causes flocculation and subsequent sedimentation of the milky white latex, providing a rapid and visible method for detecting the success of a PCR. When a PCR is unsuccessful, no amplified DNA will be present and no sedimentation will be observed.