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. 2023 Nov 4;14(3):1345–1361. doi: 10.1016/j.apsb.2023.11.005

Figure 1.

Figure 1

Characterization of biomimetic “Gemini nanoimmunoregulators”. TEM images of (A) mPDA, (B) PM@RM-T7, and (C) PR@RM-M2 (scale bar = 100 nm). (D) Fluorescence microscopic images of PF@RM-T7, FITC was doped into mPDA, and DiI was used to label RM (scale bar = 100 μm). (E) SDS-PAGE analysis of mPDA, RM, PM@RM-T7, and PR@RM-M2. (F) Z-average size and surface zeta potential of mPDA, PM, PR, PM@RM-T7, and PR@RM-M2. (G) UV–Vis absorption spectra of different formulations. (H) Hydrodynamic size of PM@RM-T7 and PR@RM-M2 in saline; (I) IR thermal images of mPDA and PM@RM-T7 (at the equivalent concentration of mPDA = 200 μg/mL) under laser irradiation (808 nm, 1.0 W/cm2, 10 min). (J) Photothermal curves of PM@RM-T7 in four cycles of laser on/off. (K) Cumulative release of Met at pH 7.4 and (L) pH 5.0 from PM and PM@RM-T7 with or without laser irradiation.